- 1 What is Prednisone? Is Prednisone a corticosteroid?
- 2 Effects of Prednisone
- 3 Prednisone: Pharmacological group
- 4 Prednisone uses. What does Prednisone treat?
- 5 Where to Buy Prednisone online? Prednisone cost without prescription
- 6 Prednisone mechanism of action. How does Prednisone work?
- 7 How to take prednisone for allergies
- 8 Prednisone side effects
- 9 Prednisone and alcohol
- 10 Frequently Asked Questions about prednisone
What is Prednisone? Is Prednisone a corticosteroid?
This drug is a synthetic analogue of the hormones cortisone and hydrocortisone, which are secreted by the adrenal cortex.
When you take the drug inside, it has greater efficiency than cortisone 4-5 times and about 3 times than hydrocortisone. Prednisone slightly increases the excretion of potassium and practically does not cause sodium and water retention in the human body.
When taking Prednisone tablets orally, its maximum accumulation in the plasma is noted after 1.5 hours. The drug is well absorbed from the gastrointestinal tract. Biotransformed through oxidation, mostly in the liver.
The drug is excreted from the body in the form of metabolites with urine and feces. Prednisone has an effect on protein, water and electrolyte, carbohydrate and fat metabolism in the human body.
Prednisone belongs to the group of glucocorticoids. He owns a number of positive properties, due to which in a short time, the body begins to work as usual.
Prednisone is characterized by:
- antiseptic functions that enable successful fight irreversible transformation of the body.
Effects of Prednisone
Prednisone is a hormonal drug. Many of us at the mention of the term “hormonal drug” immediately disappears the desire to use it. However, do not rush to turn the page.
With skillful use, hormonal medicines can be of great benefit. At the same time it is possible to minimize undesirable effects from the use of such remedies.
Prednisone acts on the work of the central nervous system and through this effect covers almost the entire human body. Prednisone relieves inflammation, suppresses the work of immunity, relieves allergic reactions, and also removes toxic substances from the body.
Prednisone affects the work of certain parts of the brain and inhibits the production of certain hormones. This effect affects the chemical composition of blood. It decreases the number of lymphocytes and eosinophils – indicators of inflammatory processes in the body, but the number of red blood cells increases.
Through the impact on the production of proteins in the body, prednisone inhibits allergic reactions and inflammatory processes.
Prednisone: Pharmacological group
Prednisone is a synthetic glucocorticosteroid preparation, a dehydrated analog of hydrocortisone. The drug has anti-inflammatory, antiallergic, immunosuppressive effects, increases the sensitivity of beta-adrenergic receptors to endogenous catecholamines.
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Prednisone uses. What does Prednisone treat?
Prednisone is used to treat:
- inflammation of the cornea in the intact mucosa; blepharitis (inflammation of the edges of the eyelids);
- allergic and chronic conjunctivitis (inflammation of the mucous membrane of the eye);
- sympathetic ophthalmia (inflammation of the lining of the eye due to injury to the other eye);
- after eye surgery;
- multiple sclerosis;
- bronchial asthma;
- chronic and acute allergies (atopic dermatitis, urticaria, food and drug allergies, angioedema, toxicoderma, pollinosis);
- rheumatic fever;
- rheumatic carditis;
- chronic and acute diseases of the joints (polyarthritis, osteoarthritis, bursitis, synovitis, rheumatoid arthritis, psoriatic and gouty arthritis, scapulohumeral periarthritis, Still’s syndrome in adults);
- inflammatory diseases of the gastrointestinal tract (local enteritis, ulcerative colitis);
- infectious mononucleosis (an infectious disease in which the palatine lymph nodes, liver, and high body temperature are enlarged);
- connective tissue diseases (dermatomyositis, scleroderma, lupus erythematosus, periarteritis nodosa);
- autoimmune diseases;
- acute pancreatitis (non-specific inflammation of the pancreas);
- hemolytic anemia;
- glomerulonephritis (kidney disease).
In addition, Prednisone is used in the following situations:
- shock during surgery;
- prevention of rejection during transplantation of tissues and organs.
Where to Buy Prednisone online? Prednisone cost without prescription
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- 30 pills – $35.94;
- 90 pills – $52.93;
- 360 pills – $129.38.
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- 180 pills – $76.35;
- 360 pills – $142.29.
Prednisone mechanism of action. How does Prednisone work?
The drug Prednisone can be used for all sorts of systemic pathologies that are inherently associated with the autoimmune process.
After taking the drug, steroid hormones along with receptors move into the cell nucleus. Once in the nucleus itself, hormones begin to interact with the effector elements that are located on the acceptor sites of chromatin.
At this point, the drug begins to interact. Short-term therapy with Prednisone has a beneficial effect on the body.
- Prednisone is able to virusodack synthesize annexin, which inhibits the active action of A2 phospholipases;
- With anti-inflammatory effect, the effectiveness of glucocorticoids is activated to stop the performance of the COX-2 complex;
- The drug Prednisone is able to stop the active movement of chromosomes in the blood vessels;
- When ummmunosuppressive performance decreases T-lymphocytes. There is an increased production of ummunoglobulins;
- With action against allergies, suppression of the synthesis of mediators causing an unpleasant condition can form;
How to take prednisone for allergies
In case of emergency (I-II art. Shock) to remove the attack adults administered 300 mg / in. Indicative intravenous doses of children: newborn – 2-3 mg / kg; preschool – 1-2 mg per kg; school – 2.1 mg / kg. It is useful to use the ointment for eczema, psoriasis, atypical dermatitis, seborrhea. The dosage tablet form (taken orally, without chewing wash down): adults recommended to take from 20 to 30 mg / day, with the transition to 5-10 mg. initial dose for children should not exceed 1.2 mg / kg / day (4-6 techniques) supporting – 300-600 mg / kg per day. Cease therapeutic treatment – consistently lowering the dose.
Solutions for injection are administered in shock: adults: 30-90 mg (1-3 ml) by slow intravenous injection or infusion. 150-300 mg in critical conditions. If you can not intravenous, intramuscular being made. Children: 2-12 months – 2-3 mg / kg, 1 14 – 1 to 2 mg / kg / in slowly. After 20 – 30 minutes, the dose can be repeated.
Prednisone should not be diluted in any injectable solutions. Eye drops: apply 3 p / day, digging for 1-2 drops.. The ointment is applied 1-3 p. / Day, a thin layer to the affected areas of the skin. In limited foci impose occlusive dressings – to improve the effect. The course of treatment – a maximum two to three weeks.
Prednisone side effects
The occurrence of adverse reactions depends on the duration of treatment with Prednisone and the size of the dose taken.
The patient may develop such side effects:
- mental disorders;
- increased blood sugar levels;
- violation of the menstrual cycle;
- reduction of resistance to infections;
- hirsutism (excessive hair growth in women);
- growth retardation in children;
- decrease in muscle bulk.
Prednisone and alcohol
Prednisone is a hormonal medicine that affects the nervous system. The range of its actions is quite wide and the drug is very popular in the treatment of many diseases. Doctors do not recommend combining prednisone with alcohol, then we will explain why.
There is a lot that everyone knows about the negative effects of alcohol on the body. Its excessive use is contraindicated even for absolutely healthy people. Patients should not think about how to drink, but how to quickly get rid of the disease. Alcoholic beverages have a detrimental effect on the patient’s body, worsening his general condition.
An even harder trial awaits all the organs when they are subject to attack not only by Prednisolone, but also by ethyl alcohol.
At the beginning of the interaction, Prednisone and ethanol act on the central nervous system in a similar way, both inhibit the inhibition process. In humans, an increased excitability is observed, the mood changes dramatically, and euphoria is replaced by depression and depression. The patient may lose orientation in space.
There are more serious complications:
Serious complications await people who are addicted to alcohol, chronic alcoholics: often everything ends for them with delirium tremens.
Ethyl alcohol initially causes the opposite reaction: immediately after its use, a drop in blood pressure is observed due to the expansion of blood vessels, but soon the vessels narrow, causing an increase in blood pressure.
There is an overdose effect, it is possible hypertensive crisis. Such is the joint activity of alcohol and Prednisone: they affect the cardiovascular system extremely negatively. The heart, like the skeletal system, suffers from the fact that Prednisone helps to reduce potassium and calcium in the tissues, alcohol activates this process.
The contractile function of the myocardium becomes worse, there is stagnation of blood in the heart, the formation of blood clots, exacerbation of existing chronic diseases. The same can be said with regard to the reaction of other important organs to the compatibility of prednisone and alcohol.
At the same time, the following organs of the body are affected:
- Gastrointestinal tract.
The simultaneous entry of ethanol and Prednisone into the blood increases the risk of exacerbation of chronic, low-intensity ailments existing in humans, the emergence of new serious diseases. This is especially difficult for the liver, since it is she who is forced to break down both Prednisone and ethyl alcohol, known as a highly toxic substance, at the same time.
In addition, alcohol can reduce the effect of the drug on the body, reduce its therapeutic properties to zero, that is, alcohol will help to prolong the recovery process and complicate it.
It is very important to give preference to a healthy lifestyle. It is not necessary to test the body for strength, especially when medication treatment with hormonal drugs is carried out, putting a significant load on the body.
Frequently Asked Questions about prednisone
How to chop?
With immediate allergic conditions prednisone administered an injection. Preference is given in / in the slow introduction for 3 minutes, then drip. If such a difficult introduction, you need to make an intramuscular injection.
When injected intra-articular injection of 25 – 50 mg in large joints, in small – 10 mg. By removing the needle from the joint space is required to bend and unbend the joint several times to hormone rather spread in the body.
Place the injection must be aseptically processed.
Could it be an allergy to the drug itself?
Allergic reactions are possible with the use of prednisone for a long time: itchy skin; hives; anaphylactic shock; ; Johnson – Stevens Angioedema, and others.
Do the risks of self-appointment there?
Yes. Use of the drug on their own without consulting a doctor can lead to a number of negative side effects and complications that can harm health. Be sure to consult your doctor.
Prednisone use: Which is better tablets or injections?
Injections of the drug will allow you to save the life of the patient without any consequences for their health in acute allergic reactions. Much faster absorbed by the body injectable form than tableting, which soon help relieve allergic attack.
The drug helps to: neutralize the effect of allergen; remove severe manifestations of systemic anaphylaxis, which leads to a violation of hemodynamics of all vital systems of the body. Buying Prednisone and Use of the drug should benefit health, the normal functioning of the body without negative consequences.
Be careful when choosing medications, be sure to consult a doctor, as self sometimes leads to fatal consequences.